Sildenafil Impurity N4 CAS 374776-34-8 (free base)
| CAS No. | 374776-34-8 (free base) |
| Molecular Formula | C18H23ClN4O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Sildenafil Impurity N4 (CAS 374776-34-8 (free base), C18H23ClN4O5SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H23ClN4O5SHCl, Sildenafil Impurity N4 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 479.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23ClN4O5S HCl |
| Molecular Weight | 479.37 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Sildenafil Standards
- Sildenafil Impurity N6 (CAS 1004455-71-3)
- Sildenafil Impurity 258 (CAS 1007310-62-4)
- Sildenafil Impurity 256 (CAS 1027192-9-2)
- Sildenafil Impurity 5 (CAS 1058653-74-9)
- Sildenafil Impurity 29 (CAS 1093065-15-6)
- Sildenafil EP Impurity B (CAS 1094598-75-0)
- Sildenafil-D3 (CAS 1126745-90-1)
- Sildenafil Impurity 62 (CAS 116833-23-9)
Recommended Standards
- Captopril Impurity 31 (CAS 69570-39-4)
- Bortezomib Impurity 24 (CAS CATO-C4X-107224)
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- (S)-1-(2,5-dimethylphenyl)-2-methylpropan-1-amine hydrochloride (CAS 1391435-34-9)
- 4-(2-Chloro-7-ethyl-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)morpholine (CAS 1221688-88-5)
- 2,2'-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole) (CAS 1222810-74-3)
- Dimethyl 4,6-diaminoisophthalate (CAS 15403-48-2)
- 3-Iodo-6,8-dioxabicyclo[3.2.1]Oct-2-en-4-one (CAS 890095-66-6)
- 7-Bromo-1-chloro-1,2,3,4-tetrahydronaphthalene (CAS 1343206-44-9)
- Neuroendocrine Regulatory Peptide-4 (human, mouse, rat) (H-7266.1000) (CAS 922704-18-5)
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